Tuesday, May 5, 2020

Business Ethics for Medical Research

Question: Discuss about the Business Ethics for Medical Research. Answer: Introduction: Taxpayers money is justified if the research is not wasteful and inefficient. According to Swan (2016), ninety percent of the medical studies are wasting money and are federally funded. As per Wolf (2016) of the National Institute of Health," 85% of the biomedical research is wastage of taxpayer money. NIH spends more than $30 billion per year on taxpayer funds. There is a need for more targeted research that is convincing, strong evidence-based links and serves national interest justified for funding (Alberici 2016). There is a need for more transparency and accountability when allocating taxpayer's money for medical science. Promising people with better health care services generates hope in people with all kinds of diseases but maximum studies research on the areas that have already been proved by others scientists (Marx 2016). However, based on podcast information related to personalized medicine and genetic research it can be said that more taxpayer money should be used in this areas as they are targeted to the particular biology of the diseases of the individual. DNA sequencing has been successful in unlocking much of the mystery of the human biology. It is helpful to take various actions to improve the health by taking individual data cloud (Swan 2016). Actionable possibilities can demand more taxpayer money than the research that does not generate any actionable opportunities. Genetic testing could be helpful in saving a lot of money by determining what should be the right drug for a given individual. Increasing cost is justified and will be accepted by the public if there are measurably better outcomes and would also satisfy the taxpayers concern. From a patients point of view tax payers money is justified for even those diseases that are not on the top of the governments finance list. In conclusion taxpayer's money is justified for evidence-based medicine and research that would yield real benefits (Radio National 2016). Genetic testing for Lynch synd rome, personalized medicine, automated DNA sequencing, genotyping, as well as discoveries like insect repellent in Aerogard and the flu drug Relenza are worth investment of huge money because risk predictions for lots and lots of diseases have great potential to improve public health (Mitchell, 2016). The genetic testing provides an opportunity for the people to predict risks and diagnosis. However, genetic tests have a little predictive value and may not supply all the information that the individual wants which cause difficulty in decision-making (Tindana et al. 2014). For example, a couple where both partners are the carrier for the cystic fibrosis mutation may desire to have the prenatal diagnosis done to identify if the fetus has cystic fibrosis mutations is being inherited from each parent. If the fetus is identified with two such mutations, then the parents will experience an ethical dilemma whether to end the pregnancy or continue despite the severity of the condition being unknown. Therefore, genetic decision leads to uncertainties for families, clinicians and other professionals involved in the process (Delbue et al. 2016). Moreover, killing a fetus if diagnosed with a disease that onsets at 50 years of age say Alzheimers then the questions arises that should a child be deprived of living 50 years? Genetic tests have several potential adverse consequences at both personal and societal level (West et al. 2014). Patients diagnosed with conditions that have no permanent cure are subjected to psychological harm, discriminations and stigmatization. They tend to end their life. For example, Hunting Diseases patients give birth to children who have 50% chance of inheriting the disease. Such patients are deprived of insurance policies or employment opportunities. Therefore ethical dilemma involves confidentiality of medical information of the patient. Ethical issue in biomedical research involves animal experimentation (Adobor 2012). Most of the animal do not suffer from the severe form of diseases as humans like heart diseases, AIDS, and others. Treatment showing success in animal laboratories may or may not work in case of humans. Animals in the laboratory are induced to mimic human diseases, but people affected by the severe disorder have multiple origins such as socioeconomic factor, genetic factors, psychological issues and other personal experiences. Experimentations in animals have been going on since several decades, however; there is no fully effective cure as yet been developed (Tindana et al. 2014). Prestigious medical journals have highlighted since time, and again that experimenting on animals wastes their life. In some countries, animals are considered sacred and experimentation is regarded as highly unethical practice (Harriss et al. 2013). In the previous years, limited research has been carried on regarding the role of human endogenous retroviruses in colon cancer. We will carry out a study to find that whether "Human Endogenous Retroviruses play a role in the development of colon cancer?" We believe that the retroviruses have the role in colon cancer. Previously, it was assumed that human endogenous retroviruses could become active and also, they are involved in the process of cell transformation using a variety of oncogenic mechanisms. It has also been reported that these proteins are expressed in and the abnormal way for different kinds of cancer like germ cell cancer, breast cancer, melanoma and prostate cancer. In these conditions, the overexpression of the encoded proteins or transcripts takes place in the tissues affected by tumor or cancer. Nonetheless, a little is known regarding the association between human endogenous retroviruses and the progression of colon cancer (Delbue et al. 2016). In this research, w e are going to re-evaluate colon cancer concerning the human endogenous retroviruses and will perform an investigation that will potentially lead to innovative diagnostics as well as therapeutic approaches in future. In this research, we will also take into consideration the strong perspective of human endogenous retroviruses family for producing proteins, which can act as good candidates for identifying the diseases, thus serving as biomarkers. Also, they can also act as targets of therapeutic approaches, particularly on the antigens that are associated with a tumor. For carrying out this research, we require funds to conduct our work. We firmly believe that our research will be successful in re-evaluating that whether the human endogenous retroviruses play a definite role in the development of colon cancer. Also, it will also be valuable for the future researchers effectively. Reference Adobe, H., 2012. Ethical issues in outsourcing: the case of contract medical research and the global pharmaceutical industry.Journal of business ethics,105(2), pp.239-255. Alberici, E. (2016). Lateline - 14/04/2014: Cuts to science funding are regressive and dangerous. [online] Abc.net.au. Available at: https://www.abc.net.au/lateline/content/2014/s3985479.htm [Accessed 30 Sep. 2016]. Delbue, S., Signorini, L., Villlani, S., Bregni, M. and Ferrante, P. (2016). Do the Human Endogenous Retroviruses Play a Role in Colon Cancer?. ATV, p.11. Harriss, D.J. and Atkinson, G., 2013. Ethical standards in sport and exercise science research: 2014 update.International journal of sports medicine,34(12), pp.1025-1028. Marx, P. (2016). Genotyping: 23andMe. [online] Radio National. Available at: https://www.abc.net.au/radionational/programs/healthreport/genotyping/5235128 [Accessed 30 Sep. 2016]. Mitchell, N. (2016). Personalised medicine - why drugs don't always work (Part 2 of 2). [online] Radio National. Available at: https://www.abc.net.au/radionational/programs/healthreport/personalised-medicine---why-drugs-dont-always-work/3162456 [Accessed 30 Sep. 2016]. Radio National. (2016). Personalised medicine: Can you trust online genetic tests? (Part 1 of 2). [online] Available at: https://www.abc.net.au/radionational/programs/healthreport/personalised-medicine-can-you-trust-online-genetic/3163472 [Accessed 30 Sep. 2016]. Swan, N. (2016). The future of DNA-sequencing. [online] Radio National. Available at: https://www.abc.net.au/radionational/programs/healthreport/the-future-of-dna-sequencing/5275000 [Accessed 30 Sep. 2016]. Tindana, P., Molyneux, C.S., Bull, S. and Parker, M., 2014. Ethical issues in the export, storage and reuse of human biological samples in biomedical research: perspectives of key stakeholders in Ghana and Kenya.BMC medical ethics,15(1), p.1. West, C.C., Murray, I.R., Gonzlez, Z.N., Hindle, P., Hay, D.C., Stewart, K.J. and Pault, B., 2014. Ethical, legal and practical issues of establishing an adipose stem cell bank for research.Journal of Plastic, Reconstructive Aesthetic Surgery,67(6), pp.745-751. Wolf, S. (2016). Genetic research. [online] Radio National. Available at: https://www.abc.net.au/radionational/programs/healthreport/genetic-research/3129034 [Accessed 30 Sep. 2016].

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